Which antipsychotic medication is associated with a higher risk of tardive dyskinesia?

Loxapine is an antipsychotic medication known to belong to the class of typical antipsychotics, which are more commonly associated with extrapyramidal side effects, including tardive dyskinesia. Tardive dyskinesia is a serious and often irreversible condition characterized by involuntary movements, primarily involving the face and extremities, and is linked to long-term use of antipsychotic medications that primarily block D2 dopamine receptors.

While other options like Aripiprazole, Sertindole, and Clozapine carry some risk of tardive dyskinesia, they are either atypical antipsychotics or have a lower overall association with this particular side effect compared to typical antipsychotics. Atypical antipsychotics, such as Aripiprazole and Clozapine, generally have a more favorable side effect profile regarding movement disorders due to their different mechanisms of action and receptor binding characteristics. As such, Loxapine stands out as being more closely linked to the development of tardive dyskinesia in clinical practice.