Which drug can be administered transdermally to treat a client with major depression?

Selegiline is a medication primarily used as an antidepressant, particularly in the treatment of major depression. What sets selegiline apart from the other options is its availability in a transdermal patch formulation. This unique delivery method allows the medication to be absorbed through the skin, providing a steady release of the drug into the bloodstream, which can enhance adherence and minimize gastrointestinal side effects that oral medications might cause.

The transdermal route is particularly beneficial for patients who may have difficulty swallowing pills or who experience significant gastrointestinal side effects from oral medications. The patch system also allows for a more stable plasma concentration of the drug, which may contribute to improved efficacy and reduced side effects.

In contrast, the other medications listed — fluoxetine, citalopram, and venlafaxine — are typically administered orally and do not have a transdermal formulation available for use in treating major depression. This makes selegiline the only option among the correct answers for the transdermal administration route in the context of major depression treatment.