Which is a common side effect of first-generation antipsychotics?

First-generation antipsychotics, also known as typical antipsychotics, are primarily used to manage symptoms of psychosis, particularly in conditions like schizophrenia. A common side effect associated with these medications is the development of extrapyramidal symptoms (EPS). These symptoms can include tremors, rigidity, bradykinesia (slow movement), and tardive dyskinesia (involuntary movements). These side effects occur because first-generation antipsychotics primarily block dopamine receptors, which is effective for alleviating psychotic symptoms but can also disrupt normal motor control pathways in the brain.

In contrast, weight gain is more commonly associated with second-generation antipsychotics. Increased energy levels and improved concentration are not typical effects of these medications; instead, many may experience increased sedation or cognitive dulling. Therefore, the association of EPS with first-generation antipsychotics makes it a key consideration for clinicians prescribing these medications and highlights the importance of monitoring patients for these side effects during treatment.