Which late extrapyramidal side effect should the nurse be aware of when a client is on chlorpromazine?

The chosen answer refers to tardive dyskinesia, a late extrapyramidal side effect that can occur after prolonged use of antipsychotic medications such as chlorpromazine. Tardive dyskinesia is characterized by repetitive, involuntary movements, which can include a worm-like motion of the tongue. This symptom arises due to long-term dopaminergic antagonism, leading to alterations in the basal ganglia, and is more common with typical antipsychotics like chlorpromazine.

Other side effects like tremors, bradykinesia, and restlessness are typically associated with early extrapyramidal symptoms (EPS), which can occur shortly after the initiation of treatment. Tremors or restlessness may manifest during the immediate period of therapy but are not categorized as late effects. Bradykinesia, involving a slowed movement, also falls under the early EPS category. Recognizing tardive dyskinesia and differentiating it from other side effects is crucial for effective management and support for clients on antipsychotic medications.