Which second-generation antidepressant can worsen uncontrolled angle closure glaucoma?

Duloxetine is known to potentially worsen uncontrolled angle-closure glaucoma due to its anticholinergic effects. Anticholinergic medications can cause pupil dilation, which may lead to an increase in intraocular pressure in individuals who have a predisposition to angle-closure glaucoma. This is particularly relevant for patients with already uncontrolled or untreated glaucoma, as the pupil dilation can exacerbate the condition, resulting in severe visual impairment or even permanent vision loss if not managed appropriately.

Understanding the pharmacological profiles of these medications highlights the importance of screening for pre-existing ocular conditions before prescribing. While other medications listed may have their own side effect profiles, they are not specifically associated with worsening angle-closure glaucoma in the same way that duloxetine is. Thus, recognizing the link between duloxetine and its risks in patients with this specific eye condition is essential for safe prescribing practices.